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Histamine is the primary inflammatory mediator suspected of being released from Mast cells into the skin when dermatographism occurs. However, other chemical mediators may also be involved.

The result of this process is that small blood vessels in the skin begin to leak. This leads to an accumulation of fluid in the skin tissue and a wheal or welt develops in the area and in the shape of the applied pressure or friction.

The release of histamine and other mediators of inflammation may be caused by allergens or may be a result of non-allergic factors. In many cases, urticaria or dermatographism is autoimmune. In other words, the body produces antibodies against itself and this triggers the release of the histamine. The mechanism of histamine release differs depending on the urticaria or dermatographism causes.

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General Information About Dermatographism

• dermatographism has no gender preference
• dermatographism has no race preference
• young adults in their 20s and 30s are most vulnerable to dermatographism
• most people with dermatographism are in good general health

The following diagram summarizes the dermatographism causes, which have been speculated as being responsible for the appearance of this skin condition.

FOOD ALLERGENS

An allergy to a food is a possible urticaria or dermatographism cause. Typical foods that can lead to this skin condition are:

• milk and cheese
• eggs
• shellfish and other fish
• nuts
• wheat and cereals
• chicken
• peas
• oranges
• synthetic and natural food additives such as nitrites, benzoates, sulphites, colourings, and artificial flavorings

ENVIRONMENTAL ALLERGENS

Certain elements in the environment are also speculated as being dermatographism causes.

• house-dust
• molds
• pollen
• change in temperature or extreme cold or heat
• domestic contact with pet animals

In addition, not necessarily considered environmental allergens, but use of personal products such as deodorant, perfume, talcum powder, cosmetic products, and latex rubber can all be dermatographism causes as well.

A common allergen that is often overlooked is dryer sheets. Regular dryer sheets contain many chemicals that can affect your skin. Therefore, as a first step, dermatographism suffers should switch to hypoallergenic dryer sheets and unscented laundry detergents.

DRUGS

One of the suspected dermatographism causes may be a drug such as:

• antibiotics (Penicillin)
• anti-inflammatory drugs such as aspirin or indomethacin
• vaccinations
• hormonal preparations
• oral contraceptives

More information on hives from drugs can be found at this page.

INFECTIONS AND INFESTATIONS

Infections and infestations may lead to the formation of dermographism. Some examples are:

• insect bites such as bee or wasp stings
• frequent bacterial infections such as urinary track, heliobacter pylori, dental, and sinus
• viral infections such as Hepatitis A, Hepatitis B, and mononucleosis
• fungal infections (candidiasis, dermatophytosis)
• protozoal infection (an infection caused by protozoa – single cell creatures)
• scabies
• parasitic infestations such as round or tape worms

SYSTEMIC ILLNESS

A systemic illness is one that affects the whole body, not just one localized area. Dermatographism or urticaria may be a sign of another internal illness. There are many such possibilities:

• connective tissue disorders
• systemic lupus erythematosus
• Rheumatic fever
• juvenile rheumatoid arthritis
• endocrine disorders
• hyperthyroidism
• hypothyroidism
• hyperparathyroidism
• neoplastic disorders
• lymphoma
• leukemia
• carcinoma (colorectal, lung, liver, ovarian)
• necrotizing vasculitis
• polymyositis
• myeloma
• Sjogren’s syndrome
• etc.

This list is broad and therefore, an individual should not panic and assume that a more serious underlying disease is responsible for the dermatographism or urticaria symptoms. However, it is a possibility that the skin condition may be an indication of some other health problem. A physician will assess the presence of an underlying health problem by by being aware of other symptoms for the various illnesses and performing diagnostic testing where required.

STRESS

Emotional stresses can be one of the dermographism causes. The effects can be direct or indirect and may act to make an individual more susceptible to possibly developing, aggravating or maintaining the presence of this skin condition. Basically, such stresses trigger the mechanism for histamine release.

For more information on stress causing dermatographism, please visit this page.

HEREDITARY FACTORS

Dermatographism or susceptibility to this skin problem can be passed on via the genetic route. In terms of frequency, this is one of the less common dermatographism causes.

OTHER FACTORS

Having any type of surgery is suspected in causing dermatographism. Some information on this can be found here.

A variety of other dermatographism causes are described in posts submitted by dermatographism sufferers at this page.

NATURAL DERMOGRAPHISM and HIVES CURE - Click Here.

Please be sure to visit the dermatographism causes survey page and the dermatographism survey results page.

Do You Have A Question About Dermographism?

If you have a question about dermographism and would like that question answered by an actual sufferer of this skin hives condition, then please ask the question in the box below. Our resident dermatographism sufferer may not have all the answers, but he can pass along his experience in dealing with this skin problem which may help you in your battle with this skin condition.

Past Questions and Answers on Dermographism

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